Still, the study from Case Western Reserve University found a clear pattern: the more gabapentin someone took, the greater the cognitive risks.
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People with 12+ prescriptions were 40% more likely to develop dementia.
They were 65% more likely to develop MCI.
This held true even after accounting for health conditions, demographics, and other medications.
But does gabapentin cause dementia?
Not necessarily. The researchers were careful to note this was an observational study, meaning that it shows a strong association — not proof of direct cause.
Also, they couldn’t analyze exact dosage or duration.
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However, the dataset was huge, and the findings aligned with other emerging concerns about gabapentin’s side effects.
Why gabapentin use has skyrocketed
Gabapentin has been around since the early ’90s, originally approved to treat epilepsy. Over the years, doctors have increasingly turned to it for nerve pain, chronic pain, post-shingles pain, and restless legs syndrome because of the fact that it’s seen as a safer alternative to opioids.
