Police have said more will be arrested after the four announced on Wednesday.
On Wednesday, police said a 31-year-old man from St Helens and another from West Derby in Liverpool had been arrested on suspicion of violent disorder,
A 39-year-old from Southport was also arrested on suspicion of violent disorder, while a 32-year-old man from Manchester with a probation address in Southport was arrested on suspicion of affray and possession of a bladed article.
A total of 53 police officers were injured, of whom 49 were from Merseyside Police. Four were from Lancashire Police.
Some of the officers were left with broken teeth, noses and ankles, the chairman of the Merseyside Police Federation told LBC on Wednesday.
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