Preheat your oven to 350°F (175°C).
In a large bowl, combine the ground beef, chopped onion, chopped bell pepper, and breadcrumbs.
Add the beaten eggs, milk, Worcestershire sauce, salt, black pepper, garlic powder, onion powder, and cayenne pepper. Mix everything together until well combined.
Transfer the meat mixture to a loaf pan and shape it into a loaf.
In a small bowl, mix together the ketchup, brown sugar, and mustard. Spread this glaze evenly over the top of the meatloaf.
Bake in the preheated oven for about 1 hour, or until the meatloaf is cooked through and the internal temperature reaches 160°F (70°C).
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