These are other health problems that can sometimes be linked to nocturnal leg cramps:

Acute kidney injury
Addison’s disease
Alcohol use disorder
Anemia
Chronic kidney disease
Cirrhosis (liver scarring)
Dehydration
Dialysis
High blood pressure (hypertension)
Hyperthyroidism (overactive thyroid), also called overactive thyroid.
Hypoglycemia
Hypothyroidism (underactive thyroid)
Lack of physical activity
Medications, such as those used to treat blood pressure and high cholesterol, and birth control pills
Muscle fatigue
Parkinson’s disease
Peripheral artery disease
Peripheral neuropathy
Pregnancy
Spinal stenosis
Type 1 diabetes
Type 2 diabetes

When to see a doctor

For most people, nighttime leg cramps are just an annoyance, sometimes something that wakes them with a start. However, some people with these cramps may need to see a healthcare provider.

Seek immediate medical attention if you experience the following:

Severe cramps that persist.
Nighttime leg cramps after coming into contact with a toxin, such as lead.

Schedule an office visit if:

You are tired during the day because leg cramps disrupt your sleep.
You experience muscle wasting and weakness along with leg cramps.

Self-Care

To help prevent leg cramps at night, try the following:

Drink plenty of fluids, but limit alcohol and caffeine.
Stretch your leg muscles or use a stationary bike for a few minutes before bed.
Loosen sheets and blankets at the foot of the bed.

To relieve leg cramps at night, try the following:

Straighten your leg and flex your foot toward your face.
Massage the muscle with ice.
Walk or shake your leg.
Take a hot shower and direct the water at the tense muscle, or take a lukewarm bath.