The study focused on whether simple lab results collected at midlife could predict exceptional longevity. Participants who eventually reached 100 were compared with peers who did not, all tested at about the same age. The research examined markers of metabolism, kidney and liver function, iron status, and inflammation. With follow-up lasting up to 35 years, the design allowed strong long-term conclusions.
Researchers used the AMORIS cohort, which includes extensive lab data from Stockholm County. This study analyzed 44,636 participants born between 1893 and 1920. Over time, 1,224 people reached age 100, the majority of them women. Swedish national registers allowed accurate tracking of diseases and deaths, and statistical methods helped identify meaningful patterns.
Twelve routine markers were analyzed, including glucose, total cholesterol, creatinine, several liver enzymes, albumin, iron, total iron-binding capacity, and uric acid. The authors later clarified that low cholesterol—not high cholesterol—was linked with reduced odds of reaching 100. Very low iron also lowered the odds.
Glucose showed one of the clearest patterns: people in the highest ranges had the lowest odds of becoming centenarians. This aligns with long-established links between high blood sugar, vascular disease, and aging.
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