Beyond the fat and fiber, avocados are loaded with bioactive compounds—phytochemicals—that exert direct anti-diabetic effects. These aren’t just minor health benefits; these are targeted biochemical actions that influence the pathways of glucose metabolism.
Avocatin B (AvoB): The Mitochondria Manager
One of the most exciting discoveries is the identification of Avocatin B (AvoB), a lipid unique to avocados. Studies have shown that AvoB specifically targets mitochondria in pancreatic beta cells and skeletal muscle. In insulin-resistant states, these mitochondria often struggle to oxidize fatty acids, leading to an accumulation of incomplete fat metabolites that interfere with insulin signaling—a phenomenon known as lipotoxicity. AvoB is believed to help restore the proper function of these mitochondria, allowing them to burn fat efficiently and thereby reducing the cellular stress that leads to insulin resistance. This is a direct, fundamental intervention in the disease process.
The Anti-Inflammatory Effect of Carotenoids and Tocopherols
Avocados are rich in lutein, zeaxanthin, and various forms of Vitamin E (tocopherols). Chronic
