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Living with arthritis means learning to navigate daily discomfort. You may already know when to rest and when to reach out for help. But what happens when symptoms go beyond the usual aches and stiffness?

Sometimes, what seems like a small issue—like unexplained fatigue or weight loss—can be a warning sign that something more serious is going on.

Here are 7 key signs of arthritis that you should never ignore, and when it’s time to speak with a doctor.

1. Persistent Joint Pain

Joint pain is often the first sign of arthritis. It may start subtly and worsen over time, flaring during physical activity or becoming more noticeable in the morning and at night.

In rheumatoid arthritis (RA), the pain may feel vague or mild at first—like a dull ache or pressure. But for many, it can suddenly become severe, often described as feeling like a broken bone or intense bruising.

When to see a doctor: If joint pain lasts more than a few weeks or worsens without a clear cause, it’s time to seek evaluation.