3. Chronic, unexplained fatigue

Fatigue linked to poor circulation is deep and persistent—it doesn’t improve with sleep. It’s not simple tiredness but complete exhaustion, making basic tasks feel overwhelming.

This occurs because when oxygen delivery drops, your body prioritizes vital organs and reduces energy elsewhere.

This kind of fatigue is often overlooked or blamed on age or stress, but if it continues unchecked, it can significantly affect your daily life.

4. Pain or cramping in the legs

Discomfort while walking, often felt as cramping or heaviness in the legs, is a sign of peripheral artery disease (PAD). This happens when leg arteries are narrowed and can’t supply enough oxygen during activity.

The pain typically subsides with rest but may worsen over time. The specific location of the pain—calves, thighs, or buttocks—can reveal where the blockage is. PAD is also a sign of widespread atherosclerosis, including in the heart and brain.

5. Sudden sweating or nausea

Unexpected sweating, even without physical exertion, can indicate heart stress. When oxygen is lacking, your nervous system may release adrenaline, leading to a cold sweat and rapid heartbeat.