While its exact cause remains unclear, Sweet syndrome is believed to stem from cytokine-driven immune responses, triggered by infections, cancers, or certain medications—including antibiotics, antiepileptics, and vaccines. Treatment with corticosteroids usually brings swift relief.
This case stands out because inhaled therapies have never before been documented as a trigger. Differential diagnoses like contact dermatitis, lupus, or urticaria were carefully excluded.
Why This Matters
Sweet syndrome’s rarity and its potential link to serious systemic diseases mean it’s often overlooked in initial diagnoses. This case highlights the critical role primary care providers play in identifying unusual reactions tied to medication changes, ensuring timely referrals and treatment.
Conclusion
This case serves as a reminder that even familiar medications—like inhalers—can occasionally trigger rare, serious immune responses. For clinicians, staying alert to sudden skin changes following medication adjustments is vital. Recognizing atypical causes of Sweet syndrome expands diagnostic awareness and can lead to faster, life-changing interventions.
