Lung cancer is on the rise in people who have never smoked, and this could be the reason. | May 18, 2025

Lung cancer has traditionally been connected to smoking; however, in recent decades, there has been a large increase in instances among those who have never smoked. This phenomena has prompted researchers to look into other risk factors, such as environmental pollution, chemical exposure, and genetic predispositions, that may impact illness development.

In 2017, almost 1.57 million new cases were reported in men and over 900,000 in women, highlighting the global scope of the issue. These findings emphasize the need of knowing the numerous factors that may contribute to the development of lung cancer in persons with no history of smoking, including environmental pollution, genetic predispositions, and lifestyle variables.

Definition and Scope of the Problem

Lung cancer is defined as the uncontrolled proliferation of cells in lung tissue, which compromises respiratory function. Although tobacco remains the leading risk factor, 10% to 20% of confirmed cases occur in people who have never smoked. According to the aforementioned study, adenocarcinoma is the most prevalent subtype, particularly among women (59.7% of female cases), accounting for 45.6% of male cases.
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